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Early Discovery E Disc
Late Discovery L Disc
Lead Optimization L Opt
IND-Enabling IND
Clinical Clin
Programs: IBIO-101
Programs: Trop-2 x CD3*
Programs: MUC16
Programs: Target 5
Programs: EGFRvIII
Programs: CCR8
Programs: Target 8
Programs: PD-1

* Developed with EngageTx bispecific platform

iBio’s technology stack delivers precision antibodies designed to minimize downstream development risk through AI-guided epitope steering and optimization of monoclonal and next-gen CD3 T-cell engager bispecific antibodies. Our team of AI and machine-learning scientists, along with our drug hunters, are engineering antibodies for hard-to-drug targets, primarily in immunotherapy for cancer. We have a pipeline of 7 immuno-oncology therapeutics and a therapeutic candidate with the potential to treat various autoimmune diseases. Driven by our commitment to innovation, we are actively developing select programs internally while maintaining the flexibility to explore collaborative opportunities through licensing our programs to strategic partners.

We have one additional candidate available for partnering – IBIO-400 for Classical Swine Fever.

We are excited about the potential therapeutic benefits of our proprietary pipeline and are looking for partners who share our passion for bringing innovative treatments to advance healthcare and improve patient lives.

To learn more about our pipeline candidates and potential partnership opportunities, please contact us.

The IBIO-100 candidates for idiopathic pulmonary fibrosis [IPF] and systemic sclerosis have been shown to address symptoms of fibrosis in highly diseased human tissue in addition to efficacy in preclinical models. Based upon work by Dr. Carol Feghali-Bostwick, the lead candidates are a fusion of the endostatin derived E4 antifibrotic peptide to the hinge and heave chain of human IgG1. Orphan drug designation was granted by the US FDA for the systemic scleroderma indication.
In collaboration with the Institute of Infectious Animal Diseases (IIAD), within the Texas A&M University System and Kansas State University, we used FastPharming®, iBio’s plant-based manufacturing system, to develop a safe and effective subunit vaccine1 capable of differentiating infected from vaccinated animals (DIVA), a key consideration for restoration of trade status2. Formulated in cost-effective oil-in-water emulsion adjuvants, IBIO-400 studies demonstrated that a single-dose of the adjuvanted, plant-made CSF E2 subunit vaccine provides protection in challenged pigs and is accompanied by strong virus neutralization antibody response.


  1. Laughlin, R.C. et al. (2019) “Plant‐made E2 glycoprotein single‐dose vaccine protects pigs against classical swine fever.” Plant Biotechnol J. 17(2):410-420.
  2. “Classical Swine Fever Response Plan: The Red Book”. Foreign Animal Disease Preparedness and Response Plan. National Center for Animal Health Emergency Management. United States Department of Agriculture, Animal and Plant Health Inspection Service. March 2013.