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Rapid Delivery of Medical Countermeasures Amid Pandemic

April 17, 2020

Immeasurable efforts are underway to develop treatments and vaccines to address the COVID-19 pandemic. Numerous discovery methods and technologies are currently being explored in clinical trials such as DNA and RNA-based vaccine candidates, adjuvant platform technologies, recombinant nanoparticles, and monoclonal antibodies, to name a few. As promising therapies begin to emerge, they’ll need to be rapidly scaled up for trials and potential commercialization, which is not without its challenges in a pandemic setting.

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Building Therapeutic Proteins through Plant Glycosylation: A Sweet Solution

February 5, 2020

N-Glycosylation is a critical component of many protein-based therapeutics, required for appropriate stability, immunogenicity, and pharmacokinetics. In addition, it is essential for key antibody activities, including ADCC (antibody-dependent cell-mediated cytotoxicity) and CDC (complement-dependent cytotoxicity). Taken all together, glycosylation is a Critical Quality Attribute (CQA) for antibodies and other proteins.

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Facilitating 3D Organ Printing with Plant-Based BioInks

December 9, 2019

There is a chronic shortage of organs available for transplant. Bioprinted organs could dramatically increase accessibility to all patients in need of transplants. Some simpler biofabricated tissues are already entering the clinic, with the promise of more complicated 3D bioprinted organs undergoing clinical trials by the middle of the next decade.  Scalable, efficient and economic manufacturing solutions for key raw materials, such as recombinant protein bioinks, growth factors and maturogens, will be essential for successful commercialization.

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Successfully Addressing the Challenges of Glycosylation

October 9, 2019

Post-translational modification is a critical step in the synthesis of biotherapeutic molecules. Among these alterations to the original naked protein, glycosylation may be the most significant and difficult to properly complete. In this roundtable, we discuss the challenges and the pitfalls involved in generating authentic glycosylated molecules in cell culture and microbial production facilities. GEN interviewed several authorities in the field of protein production.

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