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iBio is developing the next generation of cardiometabolic and obesity medicines to promote higher quality weight loss and enhance overall metabolic health and function. Current anti-obesity treatments in the incretin class, such as Glucagen-like-peptide-1s (GLP-1), have successfully reduced obesity but come with challenges. Many patients experience muscle loss as they lose fat, and side effects often lead to discontinuation of treatment.  

Our pipeline of therapeutic candidates for cardiometabolic diseases and obesity aims to preserve and build muscle mass during weight loss, prevent weight re-gain, and treat heart disease related to metabolic syndrome. We are also designing therapeutic candidates with a goal to be more convenient for patients, with less frequent dosing, and a safety and tolerability profile for potential long-term use. We envision our therapeutic candidates working alongside or following currently approved treatments such as GLP-1s. 

Beyond cardiometabolic disease and obesity, iBio has developed a pre-clinical pipeline of candidates in immuno-oncology for difficult-to-treat cancers, such as solid tumors in breast, lung, and colorectal cancer, pancreatic cancer, and glioblastoma, an aggressive form of brain cancer.  

The driver behind iBio’s pipeline is our antibody discovery platform, an integrated technology stack powered by machine learning to deliver precision antibodies for difficult targets and modes of action. With our platform, we aim to optimize the developability and functionality of our therapeutic candidates and enhance their safety.  

Our Platform is comprised of five main components: 

  • Our patented AI-driven Epitope Engineering Engine, which enables the active steering of antibody discovery to desirable binding sites on the target protein
  • Our proprietary Antibody Library of fully human sequences and a clinically validated framework
  • Our StableHu™ Antibody Optimizer for generating functionally enriched libraries from a template antibody
  • EngageTx™, a CD3 T-cell engager antibody panel for optimizing next-gen bispecifics
  • ShieldTx®, an antibody masking technology for delivering on-epitope, on-tissue clinical candidates with enhanced safety and developability

Meet Our Leadership Team

Martin Brenner headshot

Board of Directors

  1. Lyu, X. et al. The global landscape of approved antibody therapies. Antibody Therapeutics 5, 233–257 (2022).
  2. Scripps Research Humans may be capable of producing a quintillion different antibodies, January 23, 2019
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