This IL-2-sparing anti-CD25 antibody aims to reduce tumor growth by selectively depleting immunosuppressive regulatory T cells without affecting cancer-killing effector T cells. It’s being investigated as a fast follower to Hoffman-La Roche’s RG6292 molecule, with potential indications including solid tumors, hairy cell leukemia, relapsed multiple myeloma, lymphoma, and head and neck cancers.

This potential candidate is designed to selectively bind to CCR8, a protein highly expressed by regulatory T cells in the tumor microenvironment, without killing its closely related neighbor, CCR4. When CCR8 and regulatory T cells are depleted without killing CCR4, CCR4 triggers an innate immune response to selectively target and kill tumors. This target can potentially treat a broad range of solid tumor cancers, alone and in combination with checkpoint inhibitors.

TROP-2 (Trophoblast cell-surface antigen 2) is an overexpressed cell surface protein in multiple solid tumors, including breast, lung, colorectal, and pancreatic cancers. It plays a crucial role in promoting tumor growth, survival, and metastasis by regulating cell signaling pathways, adhesion, and epithelial-mesenchymal transition. Targeting TROP-2 with bispecific antibodies aims to engage the immune system to treat TROP-2-positive cancers selectively and effectively. TROP-2 can potentially treat cancers of the head and neck, lung, ovary, breast, and pancreas.

MUC16 is a tumor-associated epitope that is over-expressed and shed by tumor cells, making it difficult to kill the tumor. The antibody being investigated binds to nearby epitopes that are not shed to maintain activity against the tumor. This target can potentially treat ovarian, uterine, and pancreatic cancers.

This anti-EGFRvIII antibody is being investigated to treat glioblastoma and other cancers by selectively killing EGFRvIII tumor cells without destroying healthy tissue. The novel antibody has high antibody-dependent cellular cytotoxicity (ADCC), potentially reducing toxicity and expanding the therapeutic window. Potential indications include glioblastoma, head and neck cancer, and non-small cell lung cancer.