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Technologies

FastPharming

Icon - dials, representing the faster biopharmaceutical manufacturing abilities of FastPharming by iBio
Speed
Icon - upwards scaling, a manufacturing process which becomes easier with FastPharming
Scalability
Icon: ring of leaves. Represents reduced volume of single-use waste generated by the FastPharming manufacturing process when compared to mammalian cell culture production
Eco-Friendly
Icon: globe with checkmark on a shield, indicating reduced risk of contamination when manufacturing with iBio
Safety
Icon: diamond or crystal, representing the high-quality results yielded by Fastpharming plant-based gene expression technology
Quality
Icon: gears and currency, representing reduction in expense from using transient expression
Economy
Icon: molecule or protein with expanding arrows around it, representing the ability to use Fastpharming for biopharmaceutical manufacturing to create a range of recombinant proteins and more
Versatility

The Magic Behind the FastPharming System

N. benthamiana seeds are planted in hydroponic media and transferred to trays for gravity fed loading into LED lit vertical farming racks. Our plants are grown indoors under tightly controlled conditions for consistency & quality. Seeding & Growth Seedlings are transplanted from germination trays to larger grow trays. 1 Vector Gene ofInterest Gene Cloning We synthesize the gene, encoding the desired protein and clone it into our high-productivity FastPharming Vectors. Mobilization The gene vectors are then loaded into agrobacteria, which are ideally suited to infect the N. benthamiana plants.
2 PlantInfiltration We then submerge the plants under a vacuum in a solution containing the agrobacteria to infiltrate the microbes into the leaves, where they then deliver the gene vectors into the plant cells. plant cells
The vectors instruct the plant cells to start producing an abundance of the desired protein, converting each plant into a small factory! ProteinProduction 3
Harvesting After about a week of growth, we harvest the plant leaves and their cargo of recombinant protein. 4
We process the leaves to extract the "green juice," that then undergoes industry standard protein purification before finishing the biologic in its final form. Purification & Vialing 5

Speed To Clinic

TImeline graph of time required to develop a concept into a GMP substance using Fastpharming gene and protein expression, which is as little as 3 months
Timeline graph of the amount of time required to move from infiltration-ready plants to a drug substance. As little as 14 days, when compared to around 40 days or more with other technologies
  • Rapid Agrobacterium vector availability accelerates the timeline to Master Cell Bank (MCB) generation by as much as 10 months​
  • Bulk drug substance manufacturing timeline reduced because host plants can be ready on-demand thereby eliminating the seed train​
  • Rapid production timeline can support earlier preclinical safety and product stability studies which can potentially further reduce time to IND
Mammalian cell culture timelines given above are for illustrative purposes only based upon competitive data from publicly available sources.  Actual timelines may vary.
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