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Plant-Made Antibodies Show Superior Glycosylation Homogeneity While Retaining Pharmacokinetic Properties

May 3, 2022

Monoclonal antibodies (mAbs) are a key class of biologic drugs. Their expression in alternative platforms, including plant-based systems, can provide a range of advantages. Two well-known mAbs, NISTmAb and rituximab, were produced in Nicotiana benthamiana and displayed increased homogeneity in their glycosylation pattern vs CHOmade analogs, while retaining similar pharmacokinetic properties. We believe these data support plant expression systems as promising alternatives for producing therapeutic mAbs for unmet medical needs.

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